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PH Dane-acid

D(-)-4-Hydroxyphenylglycine

CAS: 22818-40-2

Molecular Formula: C8H9NO3

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PH Dane-acid - Names and Identifiers

Name D(-)-4-Hydroxyphenylglycine
Synonyms PH Dane-acid
H-D-Phg(4-OH)-OH
D-p-hydroxyphenylglycine
D-4-Hydroxyphenylglycine
4-HYDROXY-D-PHENYLGLYCINE
4-Hydroxy-D-Phenylglycine
(R)-4-HYDROXYPHENYLGLYCINE
D(-)-4-Hydroxyphenylglycine
D(-)4-P-hydroxyphenylglycine
D-(-)-4-Hydroxyphenylglycine
(R)-2-(4-Hydroxyphenyl)glycine
(2R)-2-amino-2-phenylethanamide
D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
2-(4-Hydroxy-phenyl)glycin D-Form
(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE
(2R)-amino(4-hydroxyphenyl)ethanoic acid
(R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID
(R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID
(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID
(r)-alpha-amino-4-hydroxybenzeneacetic acid
(R)-(-)-alpha-Amino-(4-hydroxyphenyl)acetic acid
CAS 22818-40-2
EINECS 245-247-7
InChI InChI=1/C8H10N2O/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H2,10,11)/t7-/m1/s1

PH Dane-acid - Physico-chemical Properties

Molecular FormulaC8H9NO3
Molar Mass167.16
Density1.396
Melting Point240°C (dec.)(lit.)
Boling Point295.73°C (rough estimate)
Specific Rotation(α)-156 º (c=1, 1 N HCl)
Flash Point149°C
Water Solubility5 g/L (20 ºC)
Solubility 5g/l
Vapor Presure0Pa at 25℃
AppearanceWhite crystal
ColorClear colorless to yellow
BRN2210998
pKa2.15±0.10(Predicted)
Storage Condition2-8°C
Refractive Index-158 ° (C=1, 1mol/L
MDLMFCD00004262
Physical and Chemical PropertiesMelting point 240°C
specific optical rotation -156 ° (c = 1, 1 N HCl)
water-soluble 5g/L (20°C)
UseUsed as pharmaceutical intermediates, mainly for semi-synthetic penicillin, amoxicillin, cephalosporins and other pharmaceutical synthesis
D-p-hydroxyphenylglycine is mainly used for the preparation of D-p-hydroxyphenylglycine salt (M · K) and OH-EPCP.

PH Dane-acid - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S24/25 - Avoid contact with skin and eyes.
WGK Germany3
TSCAYes
HS Code29225000

PH Dane-acid - Upstream Downstream Industry

Raw MaterialsPhenol
(2R,3R)-2,3-Dihydroxybernsteinsaeure
Glyoxal

PH Dane-acid - Nature

Open Data Verified Data

crystalline solid, melting point 240 ° C. (decomposition).

Last Update：2024-01-02 23:10:35

PH Dane-acid - Preparation Method

Open Data Verified Data

anisaldehyde is prepared by cyclization, hydrolysis, esterification and resolution.

Last Update：2022-01-01 10:54:50

PH Dane-acid - Introduction

Slightly soluble in ethanol and water, easily soluble in acid or alkali solution to form salt.
Last Update：2022-10-16 17:15:05

PH Dane-acid - Application

Open Data Verified Data

Medicine for the synthesis of ceftrimazine, cefadroxil, cefoperazone, amoxicillin and other drugs.

Last Update：2025-08-19 16:24:40

PH Dane-acid - Safety

Open Data Verified Data

25kg cardboard barrel, lined with plastic bag.

Last Update：2022-01-01 10:54:50
PH Dane-acid
Supplier List
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: 4-Hydroxy-D-phenylglycine Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
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Hubei Rhema Reference Materials Technology Co., Ltd.
Spot supply
Product Name: Amoxicillin EP Impurity I Request for quotation
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Nantong Reform Petro-Chemical CO., LTD.
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Shanghai Amole Biotechnology Co., Ltd.
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: (αR)-α-Amino-4-hydroxybenzeneacetic acid Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
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MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: D-(-)-4-Hydroxyphenylglycine (Standard); 4-Hydroxy-D-phenylglycine (Standard) Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
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SKYRUN INDUSTRIAL CO.,LTD
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CAS: 22818-40-2
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 22818-40-2
Tel: 0086-551-65418684
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: 4-Hydroxy-D-phenylglycine Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: 4-Hydroxy-D-phenylglycine Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: D(-)-4-Hydroxyphenylglycine Request for quotation
CAS: 22818-40-2
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Hubei Rhema Reference Materials Technology Co., Ltd.
Spot supply
Product Name: Amoxicillin EP Impurity I Request for quotation
CAS: 22818-40-2
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249 Click to send a QQ message
Wechat: 15787876101
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: D(-)-4-Hydroxyphenylglycine Request for quotation
CAS: 22818-40-2
Tel: +86-13776910623
Email: r@reformchem.com­
Mobile: +86-13776910623
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: H-D-Phg(4-OH)-OH Request for quotation
CAS: 22818-40-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: (αR)-α-Amino-4-hydroxybenzeneacetic acid Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: D-(-)-4-Hydroxyphenylglycine (Standard); 4-Hydroxy-D-phenylglycine (Standard) Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: D(-)-4-Hydroxyphenylglycine Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: D(-)-4-Hydroxyphenylglycine Request for quotation
CAS: 22818-40-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: 4-Hydroxy-D-phenylglycine Visit Supplier Webpage Request for quotation
CAS: 22818-40-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
PH Dane-acid
2--5- fluoropyridinebroMide
lithium trimethylsilanolate
215433-53-7
BENZYL TRIBUTYL AMMONIUM CHLORIDE BTBAC
Chloropotassuril
Bensulfuron-Methyl
Diethylene Glycol Butyl Ether
CCS-1477
Phenobarbital SodiuM API
Raw Materials for PH Dane-acid
Phenol
(2R,3R)-2,3-Dihydroxybernsteinsaeure
Glyoxal
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